EARLY SEQUENTIAL LESIONS DURING DEVELOPMENT OF EXPERIMENTAL GASTRIC-CANCER WITH SPECIAL REFERENCE TO DYSPLASIAS

被引:33
作者
KUNZE, E [1 ]
SCHAUER, A [1 ]
EDER, M [1 ]
SEEFELDT, C [1 ]
机构
[1] UNIV MUNICH,INST PATHOL,D-8000 MUNICH 22,FED REP GER
关键词
Early cancer; N-methyl-N′-nitro-N-nitrosoguanidine-Carcinogenesis of gastric mucosa-Dysplasias;
D O I
10.1007/BF00410646
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The early sequential development of gastric cancer was studied with experimental animals and examined with respect to what conclusions can be drawn for understanding carcinogenesis in man. After limited oral administration of N-methyl-N′nitro-N-nitrosoguanidine to 174 rats carcinomas developed in most cases directly from the otherwise unchanged mucosa through various successive stages of transformation, without passing through a benignappearing proliferative or neoplastic epithelial lesion. Focal dysplasia grade I was the first recognizable change observed by light microscopy, followed by dysplasia grade II, and subsequently dysplasia grade III. In spite of very similar morphological characteristics, the experimentally induced dysplasias cannot be simply equated in their etiology and biological behavior with the dysplasias of the human stomach. Dysplasias of grade I and II commonly found in man are usually associated with a chronic gastritis; they are located in the upper third of the mucosa and are for the most part reversible. The experimental dysplasias occuring in the proliferative zone of an otherwise undisturbed mucosa must be considered potentially premalignant, as they are irreversible and develop progressively. This finding points out that in man dysplasias grade III within the regenerative zone of non-inflammatory mucosa should be considered particularly as possible precursors of gastric carcinomas. © 1979 Springer-Verlag.
引用
收藏
页码:247 / 264
页数:18
相关论文
共 57 条
[1]  
BOCIAN JJ, 1958, ARCH PATHOL, V65, P6
[2]  
BORCHARD F, 1976, VERH DTSCH GES PATHO, V60, P452
[3]  
BRALOW SP, 1970, CANCER RES, V30, P1215
[4]   EXPERIMENTAL GASTRIC CARCINOGENESIS [J].
BRALOW, SP .
DIGESTION, 1972, 5 (05) :290-&
[5]   EARLY GASTRIC CARCINOMA [J].
CAIN, H ;
KRAUS, B .
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT, 1973, 98 (35) :1591-1596
[6]   ZUR ERZEUGUNG SUBCUTANER SARKOME AN RATTEN - CARCINOGENE WIRKUNG VON HYDRAZODICARBONSAURE-BIS-(METHYL-NITROSAMID) N-NITROSO-N-N-BUTYL-HARNSTOFF N-METHYL-N-NITROSO-NITROGUANIDIN UND N-NITROSO-IMIDAZOLIDON [J].
DRUCKREY, H ;
PREUSSMANN, R ;
IVANKOVIC, S ;
SO, BT ;
SCHMIDT, CH ;
BUCHELER, J .
ZEITSCHRIFT FUR KREBSFORSCHUNG, 1966, 68 (01) :87-+
[7]   EARLY GASTRIC CANCER - EXPERIENCE IN GERMANY [J].
ELSTER, K ;
KOLACZEK, F ;
SHIMAMOTO, K ;
FREITAG, H .
ENDOSCOPY, 1975, 7 (01) :5-10
[8]  
ELSTER K, 1978, LEBER MAGEN DARM, V8, P319
[9]   REVIEW OF 5 CASES OF EARLY GASTRIC CARCINOMA [J].
FEVRE, DI ;
GREEN, PHR ;
BARRATT, PJ ;
NAGY, GS .
GUT, 1976, 17 (01) :41-47
[10]  
FUJIMURA S, 1970, CANCER RES, V30, P1444