EFFECT OF BILATERAL ADRENALECTOMY ON VIP RECEPTOR EFFECTOR SYSTEM IN RAT INTESTINAL EPITHELIAL-CELLS

被引：1

作者：

FERNANDEZMORENO, MD ^{[1
]}

CARRERO, I ^{[1
]}

ARILLA, E ^{[1
]}

PRIETO, JC ^{[1
]}

机构：

[1] UNIV ALCALA DE HENARES, DEPT BIOQUIM & BIOL MOLEC, E-28871 ALCALA DE HENARES, SPAIN

来源：

BIOSCIENCE REPORTS | 1990年 / 10卷 / 02期

关键词：

adrenalectomy; cyclic AMP; dexamethasone; VIP;

D O I：

10.1007/BF01116575

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The number of vasoactive intestinal peptide (VIP) receptors and the efficiency of VIP in the stimulation of cyclic AMP accumulation in rat jejunal epithelial cells increased after bilateral adrenalectomy. However, this condition increased neither receptor affinity nor VIP potency. In addition, jejunal VIP levels followed a parallel increase. These changes reversed to control conditions after glucocorticoid replacement with dexamethasone indicating that adrenalectomy modifies the intestinal VIP receptor/effector system and suggest a relationship between corticosteroids and VIP in the functions of intestinal epithelium. © 1990 Plenum Publishing Corporation.

引用

页码：165 / 171

页数：7

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