EFFECT OF BLOOD-VISCOSITY ON ARTERIAL FLOW INDUCED DILATOR RESPONSE

被引：34

作者：

MELKUMYANTS, AM

BALASHOV, SA

机构：

[1] Department of Circulation Biomechanics and Control, Institute of Experimental Cardiology, USSR Cardiology Research Centre, 121552 Moscow, 3rd Cherepkovskaya Str

来源：

CARDIOVASCULAR RESEARCH | 1990年 / 24卷 / 02期

关键词：

Blood flow; Blood viscocity; Endothelium; Shear stress; Vasodilatation;

D O I：

10.1093/cvr/24.2.165

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Experiments were designed to determine whether blood viscocity affects flow induced dilator response in conduit arteries. Changes in diameter of the femoral artery of anaesthetised cats evoked by stepwise blood flow increases were recorded at normal blood viscocity, at haemodilution, and at haemoconcentration, under conditions of stabilised transmural pressure. Dilator responses caused by the same increments in flow rate increased at haemoconcentration and decreased at haemodilution, in parallel with the changes in blood viscocity. These data show that haemodilution attenuates and haemoconcentration augments flow induced dilatation, and they confirm the suggestion that flow induced arterial dilatation is due to endothelial sensitivity to shear stress.

引用

页码：165 / 168

页数：4

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