IDENTIFICATION BY ANTIIDIOTYPE ANTIBODIES OF AN INTRACELLULAR MEMBRANE-PROTEIN THAT RECOGNIZES A MAMMALIAN ENDOPLASMIC-RETICULUM RETENTION SIGNAL

Monoclonal antibodies were raised against antibodies to distinct carboxy-terminal KDEL sequences of two soluble, resident endoplasmic reticulum proteins. These anti-idiotype reagents recognize an intrinsic membrane protein with characteristics expected of a receptor responsible for the recognition and return of resident proteins to the endoplasmic reticulum. © 1990 Nature Publishing Group.