MAPPING OF MULTIPLE SUBUNITS OF THE NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTOR TO CHROMOSOME-15 IN MAN AND CHROMOSOME-9 IN MOUSE

被引：36

作者：

ENG, CM

KOZAK, CA

BEAUDET, AL

ZOGHBI, HY

机构：

[1] BAYLOR UNIV,DEPT PEDIAT,HOUSTON,TX 77030

[2] BAYLOR UNIV,HOWARD HUGHES MED INST,HOUSTON,TX 77030

[3] NIAID,MOLEC MICROBIOL LAB,BETHESDA,MD 20892

来源：

GENOMICS | 1991年 / 9卷 / 02期

关键词：

D O I：

10.1016/0888-7543(91)90253-B

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The α3, α5, and β4 genes (human gene symbols CHRNA3, CHRNA5, and CHRNB4 respectively; mouse gene symbols Acra-3, Acra-5, and Acrb-4, respectively) are members of the nicotinic acetylcholine receptor gene family and are clustered within a 68-kb segment of the rat genome (Boulter et al., 1990, J. Biol. Chem. 265: 4472). By somatic cell hybrid analysis, three cDNAs corresponding to these genes were used to map the homologous loci to human chromosome 15 and to mouse chromosome 9. Linkage analysis using CEPH pedigrees showed that the CHRNA5 gene was closely linked to the following chromosome 15 loci: D15S46, D15S52, D15S28, D15S34, and D15S35. Using interspecies crosses in mice, the Acra-5 gene was found closely linked to the Mpi-1 locus. The mapping of these members of a neurotransmitter receptor gene family may facilitate the identification of relationships between the neurotransmitter receptors and murine or human phenotypes. © 1991.

引用

页码：278 / 282

页数：5

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