GLUCOCORTICOIDS SUPPRESS THE PRODUCTION OF INTERLEUKIN-4 BY HUMAN-LYMPHOCYTES

被引：138

作者：

WU, CY ^{[1
]}

FARGEAS, C ^{[1
]}

NAKAJIMA, T ^{[1
]}

DELESPESSE, G ^{[1
]}

机构：

[1] UNIV MONTREAL, NOTRE DAME HOSP, RES CTR, 1560 SHERBROOKE ST E, MONTREAL H2L 4M1, QUEBEC, CANADA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1991年 / 21卷 / 10期

关键词：

D O I：

10.1002/eji.1830211053

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Given that glucocorticoids (GCS) were reported to increase the production of interleukin 4 (IL4) by mouse T cells and that GCS are widely used to treat allergic diseases it was important to examine the effect of these agents on IL4 production by human lymphocytes. We here demonstrate that the production of IL4 by human lymphocytes is markedly inhibited by small concentrations of hydrocortisone. The suppression is observed at the protein and at the mRNA levels and it is not secondary to the GCS-induced inhibition of IL2 production.

引用

页码：2645 / 2647

页数：3

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