INVITRO SUSCEPTIBILITY OF THE FISH PATHOGEN AEROMONAS-SALMONICIDA TO FLUMEQUINE

被引：14

作者：

BARNES, AC ^{[1
]}

LEWIN, CS ^{[1
]}

HASTINGS, TS ^{[1
]}

AMYES, SGB ^{[1
]}

机构：

[1] DEPT AGR & FISHERIES SCOTLAND,MARINE LAB,ABERDEEN AB9 8DB,SCOTLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1991年 / 35卷 / 12期

关键词：

D O I：

10.1128/AAC.35.12.2634

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The activity of the fluoroquinolone flumequine was investigated against the fish pathogen Aeromonas salmonicida and was compared with that of oxolinic acid. Flumequine was more active than oxolinic acid in terms of its MIC against oxolinic acid-resistant isolates of A. salmonicida and was as active as oxolinic acid against susceptible isolates. In contrast to oxolinic acid, flumequine was bacterial, with only 1% of the bacteria surviving 6 h of exposure to the drug at concentrations slightly above the MIC. Mutation to resistance to flumequine was found to occur at a lower frequency than that to oxolinic acid. Hence, in vitro, flumequine appears to possess some advantages over oxolinic acid against this fish pathogen.

引用

页码：2634 / 2635

页数：2

共 11 条

[1] CONTROL OF FURUNCULOSIS BY OXOLINIC ACID [J].

AUSTIN, B ;

RAYMENT, J ;

ALDERMAN, DJ .

AQUACULTURE, 1983, 31 (2-4) :101-108

[2] INVITRO ACTIVITIES OF 4-QUINOLONES AGAINST THE FISH PATHOGEN AEROMONAS-SALMONICIDA [J].

BARNES, AC ;

LEWIN, CS ;

HASTINGS, TS ;

AMYES, SGB .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (09) :1819-1820

[3] PLASMID-MEDIATED 4-QUINOLONE RESISTANCE - A REAL OR APPARENT ABSENCE [J].

COURVALIN, P .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (05) :681-684

[4]

ENDO T, 1973, B JPN SOC SCI FISH, V39, P165

[5] RESISTANCE OF AEROMONAS-SALMONICIDA TO OXOLINIC ACID [J].

HASTINGS, TS ;

MCKAY, A .

AQUACULTURE, 1987, 61 (3-4) :165-171

[6]

HUSTVEDT SO, 1991, PROBLEMS CHEMOTHERAP

[7] 4-QUINOLONES AND THE SOS RESPONSE [J].

LEWIN, CS ;

HOWARD, BMA ;

RATCLIFFE, NT ;

SMITH, JT .

JOURNAL OF MEDICAL MICROBIOLOGY, 1989, 29 (02) :139-144

[8]

SCALLAN A, 1985, FISH SHELLFISH PATHO

[9] MUTATIONAL RESISTANCE TO 4-QUINOLONE ANTIBACTERIAL AGENTS [J].

SMITH, JT .

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 1984, 3 (04) :347-350

[10]

SYVERTSEN C, 1989, DISEASES FISH SHELLF

← 1 2 →