LATERAL HYPOTHALAMIC-LESIONS CAUSE GASTRIC INJURY BY STIMULATING GASTRIC CONTRACTILITY

被引：8

作者：

GARRICK, T

GRIJALVA, CV

TRAUNER, M

机构：

[1] W LOS ANGELES VET AFFAIRS MED CTR, CTR ULCER RES & EDUC, DEPT RES, LOS ANGELES, CA 90073 USA

[2] UNIV CALIF LOS ANGELES, SCH MED, DEPT PSYCHIAT, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, DEPT PSYCHOL, LOS ANGELES, CA 90024 USA

来源：

AMERICAN JOURNAL OF PHYSIOLOGY | 1993年 / 265卷 / 01期

关键词：

GASTRIC MOTILITY; PEPTIC ULCERS; GASTRIC MUCOSAL DAMAGE;

D O I：

10.1152/ajpgi.1993.265.1.G138

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Changes in gastric contractility following lateral hypothalamic (LH) lesions with and without bilateral cervical vagotomy were measured in urethan-anesthetized rats. LH lesions were induced with direct current passed through stereotaxically placed electrodes. Gastric contractility was recorded continuously for 4 h with acutely implanted strain gauge force transducers and analyzed by computer. LH lesions consistently stimulated gastric contractility and caused more gastric mucosal injury than control conditions. Vagotomy blocked both gastric mucosal injury and high-amplitude gastric contractions. In rats with LH lesions and exogenously infused intragastric hydrochloric acid, atropine methyl nitrate inhibited high-amplitude gastric contractions and gastric erosions. These findings indicate that LH lesions stimulate vagally mediated high-amplitude gastric contractions, which, in the presence of hydrochloric acid, cause gastric mucosal erosions.

引用

页码：G138 / G142

页数：5

共 39 条

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