RADIATION-CHEMISTRY OF THE HIPPOCAMPAL BRAIN SLICE

被引:4
作者
MYERS, LS
CARMICHAEL, AJ
PELLMAR, TC
机构
[1] Armed Forces Radiobiology Research Institute, Bethesda, MD 20889-5603
来源
LIFE SCIENCES AND SPACE RESEARCH XXV(2): RADIATION BIOLOGY | 1994年 / 14卷 / 10期
关键词
D O I
10.1016/0273-1177(94)90499-5
中图分类号
V [航空、航天];
学科分类号
08 ; 0825 ;
摘要
The in vitro hippocampal brain slice is a 0.4 mm thick neural network that can be used to study brain responses to radiation and related injuries. This preparation is unique in that it responds to ionizing radiation within minutes after exposure without complications from changes in vascularity, blood flow, blood pressure, etc. Electrophysiological studies have shown that x- and gamma-rays alter synaptic transmission and spike generation, elements of normal brain activity. To evaluate the role of hydroxyl free radicals (.OH) in these changes, slices were exposed to dilute H2O2 solutions. EPR spin trapping experiments verified that OH is produced. Neural responses, while similar, were not identical to those due to radiation, possibly because;of a different distribution of .OH. Although H2O2 is freely diffusible, it produces .OH at specific sites where, e.g. iron reduces it. In contrast, x- and gamma-rays produce .OH more uniformly throughout the tissue. H2O2 may provide a better model for high-LET radiation where yields of radical products of water radiolysis are decreased and peroxide reactions predominate.
引用
收藏
页码:453 / 456
页数:4
相关论文
共 12 条
[1]   SPIN TRAPPING - ELECTRON-SPIN-RESONANCE PARAMETERS OF SPIN ADDUCTS [J].
BUETTNER, GR .
FREE RADICAL BIOLOGY AND MEDICINE, 1987, 3 (04) :259-303
[2]  
Halliwell B., 1989, FREE RADICAL BIO MED, P160
[3]  
LAVERNE JA, 1989, RADIAT PHYS CHEM, V34, P135
[4]   TRACK EFFECTS IN RADIATION-CHEMISTRY - PRODUCTION OF HO2. IN THE RADIOLYSIS OF WATER BY HIGH-LET NI-58 IONS [J].
LAVERNE, JA ;
SCHULER, RH .
JOURNAL OF PHYSICAL CHEMISTRY, 1987, 91 (26) :6560-6563
[5]  
LAVERNE JA, 1987, J PHYS CHEM-US, V91, P1987
[6]   ELECTROPHYSIOLOGICAL CORRELATES OF PEROXIDE DAMAGE IN GUINEA-PIG HIPPOCAMPUS INVITRO [J].
PELLMAR, T .
BRAIN RESEARCH, 1986, 364 (02) :377-381
[7]   OXIDATIVE DAMAGE IN THE GUINEA-PIG HIPPOCAMPAL SLICE [J].
PELLMAR, TC ;
NEEL, KL .
FREE RADICAL BIOLOGY AND MEDICINE, 1989, 6 (05) :467-472
[8]   FREE-RADICALS MEDIATE PEROXIDATIVE DAMAGE IN GUINEA-PIG HIPPOCAMPUS INVITRO [J].
PELLMAR, TC ;
NEEL, KL ;
LEE, KH .
JOURNAL OF NEUROSCIENCE RESEARCH, 1989, 24 (03) :437-444
[9]   ROLE OF GLUTATHIONE IN REPAIR OF FREE-RADICAL DAMAGE IN HIPPOCAMPUS INVITRO [J].
PELLMAR, TC ;
RONEY, D ;
LEPINSKI, DL .
BRAIN RESEARCH, 1992, 583 (1-2) :194-200
[10]   TIME-DEPENDENT AND DOSE-DEPENDENT CHANGES IN NEURONAL-ACTIVITY PRODUCED BY X-RADIATION IN BRAIN-SLICES [J].
PELLMAR, TC ;
SCHAUER, DA ;
ZEMAN, GH .
RADIATION RESEARCH, 1990, 122 (02) :209-214