RESIDENT RESEARCH AWARD - PULMONARY HYPOXIA INCREASES ENDOTHELIN-1 GENE-EXPRESSION IN SHEEP

被引:23
作者
DONAHUE, DM
LEE, ME
SUEN, HC
QUERTERMOUS, T
WAIN, JC
机构
[1] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02114
[2] MASSACHUSETTS GEN HOSP,THORAC SURG UNIT,BOSTON,MA 02114
[3] MASSACHUSETTS GEN HOSP,CARDIAC UNIT,BOSTON,MA 02114
关键词
D O I
10.1006/jsre.1994.1145
中图分类号
R61 [外科手术学];
学科分类号
摘要
The hypoxic pulmonary vasoconstrictor response (HPVR) is a physiologic mechanism for directing pulmonary blood flow to nonhypoxic regions of the lung. The mechanism of this response remains unclear. To investigate the role of endothelin-1 (ET-1), a potent vasoconstrictor produced by vascular endothelium, in HPVR an in vivo model of alveolar hypoxia was developed. When one lung in an anesthetized sheep was made hypoxic, the static ET-1 mRNA levels in lung tissue increased in proportion to the observed decrease in pulmonary blood flow (Q(p)) to that lung. With reversal of hypoxia, Q(p) and ET-1 levels returned to baseline. This relationship between alveolar hypoxia and ET-1 mRNA levels suggests a role for ET-1 in the local pulmonary response to hypoxia. (C) 1994 Academic Press, Inc.
引用
收藏
页码:280 / 283
页数:4
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