INNERVATION OF THE SHEEP ADRENAL-CORTEX - AN IMMUNOHISTOCHEMICAL STUDY WITH RAT CORTICOTROPHIN-RELEASING FACTOR ANTISERUM

被引:29
作者
RUNDLE, SE
CANNY, BJ
ROBINSON, PM
FUNDER, JW
机构
[1] PRINCE HENRYS HOSP, MED RES CTR, STAKILDA RD, MELBOURNE, VIC 3004, AUSTRALIA
[2] UNIV MELBOURNE, DEPT ANAT, PARKVILLE, VIC 3052, AUSTRALIA
关键词
D O I
10.1159/000124983
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Using indirect immunohistochemistry and an antiserum raised against rat corticotrophin-releasing factor (CRF) we have outlined as asymmetric network of cells and varicose fibers in sheep adrenal cortex. This network was not associated with the larger splanchnic nerves, but was occasionally found in small bundles or with blood vessels; in most instances fibers were found weaving independently through cortical parenchyma. A plexus of fibers was found in the zona reticularis, with a few fibers ramifying into adjacent medulla. Uni or bipolar cells were found throughout the cortex, with the greatest frequency at the corticomedullary junction; a multipolar-type cell was also found in this area. Staining of varicose structures and most cells was abolished by incubation with excess rat CRF 1-41, but not by ovine CRF or a range of other peptides. Though the immunoreactive species has not as yet been identified, it may thus share homology with sequences present in rat but not ovine CRF.
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页码:8 / 15
页数:8
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