MODULATION OF TOLERANCE TO THE LETHAL EFFECT OF MORPHINE BY EXTINCTION

被引：33

作者：

SIEGEL, S ^{[1
]}

HINSON, RE ^{[1
]}

KRANK, MD ^{[1
]}

机构：

[1] MCMASTER UNIV,DEPT PSYCHOL,HAMILTON L8S 4K1,ONTARIO,CANADA

来源：

BEHAVIORAL AND NEURAL BIOLOGY | 1979年 / 25卷 / 02期

关键词：

D O I：

10.1016/S0163-1047(79)90610-1

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

In contrast with previous demonstrations that tolerance to the analgesic and thermic effects of morphine can be extinguished by repeated placebo administrations, Sklar and Amit (1978, Behavioral Biology, 22, 509-514) purportedly demonstrated that tolerance to morphine-induced mortality is not affected by such an extinction procedure. The results of the present experiment demonstrated that rats administered a fatal dose of morphine following a tolerance-extinction procedure died more quickly than rats with the same pharmacological history but without the extinction experience. The results suggest that learning is involved in tolerance to lethal doses of morphine. © 1979 Academic Press, Inc.

引用

页码：257 / 262

页数：6

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