GALANIN INHIBITS SOMATOSTATIN RELEASE BY THE RAT ISLET CELL TUMOR IN CULTURE, RIN-M

被引：6

作者：

AMIRANOFF, B

LORINET, AM

LABURTHE, M

机构：

[1] Unité de Recherches sur la Différenciation el la Neuroendocrinologie, Cellules Digestives. INSERM U178, 94807 Villejuif Cedex

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 191卷 / 03期

关键词：

GALANIN; SOMATOSTATIN RELEASE; RIN-M CELLS; G-PROTEINS (GUANINE NUCLEOTIDE-BINDING PROTEINS);

D O I：

10.1016/0014-2999(90)94174-V

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Using a rat islet cell tumor in culture, Rin-m, we studied the effects of the neuropeptide, galanin, on somatostatin release. Galanin applied to the incubation medium inhibited pancreatic hormone release rapidly and dose dependently with an IC50 at 4 nM and the maximal effect (40% inhibition) was elicited by 100 nM peptide. Pretreatment of Rin-m cells with pertussis toxin abolished the inhibitory effect of galanin on somatostatin release. The results suggest that galanin probably controls the function of the pancreatic delta cell through a pertussis toxin-sensitive pathway.

引用

页码：401 / 405

页数：5

共 23 条

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