CON A-NONREACTIVE HUMAN ALPHA-1-ACID GLYCOPROTEIN (AGP) IS MORE EFFECTIVE IN MODULATION OF LYMPHOCYTE-PROLIFERATION THAN CON A-REACTIVE AGP SERUM VARIANTS

被引:82
作者
POS, O [1 ]
OOSTENDORP, RAJ [1 ]
VANDERSTELT, ME [1 ]
SCHEPER, RJ [1 ]
VANDIJK, W [1 ]
机构
[1] FREE UNIV AMSTERDAM,DEPT PATHOL & IMMUNOL,1007 MC AMSTERDAM,NETHERLANDS
关键词
D O I
10.1007/BF00917452
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Human α1-acid glycoprotein (AGP) has been shown to modulate various cellular and humoral immune reactions in vitro. Using glycosidase-modified derivatives of AGP, the importance of its carbohydrate moiety with regard to these effects has been noted. In normal serum, three molecular AGP forms interacting differently with concanavalin A (Con A) are present. The ratio of these forms is often changed during various physiopathological conditions. In this study, we could show that differences exist between the three AGP forms with regard to their immunomodulatory effectiveness. At physiological concentrations, the Con A-nonreactive variant AGP-A induced a stronger inhibition of the anti-CD3 stimulated lymphocyte proliferation than the other forms. Interestingly, AGP-A was also found to be responsible for the stimulation of lymphocyte proliferation induced by low AGP concentrations in vitro. Both immunomodulatory effects of AGP were abrogated by desialylation of the glycoprotein. These results support an immunomodulatory role of AGP in conditions characterized by a changed ratio of the differently glycosylated AGP forms. © 1990 Plenum Publishing Corporation.
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页码:133 / 141
页数:9
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