ASSOCIATION OF THE COMPLEMENT ALLELE C4AQ0 WITH PRIMARY SJOGRENS-SYNDROME IN JAPANESE PATIENTS

被引：12

作者：

MORIUCHI, J

ICHIKAWA, Y

TAKAYA, M

SHIMIZU, H

TSUJI, K

WAKISAKA, A

DAWKINS, R

ARIMORI, S

机构：

[1] TOKAI UNIV,SCH MED,DEPT TRANSPLANTAT,ISEHARA,KANAGAWA 25911,JAPAN

[2] HOKKAIDO UNIV,SCH MED,DEPT PATHOL,SAPPORO,HOKKAIDO 060,JAPAN

[3] QUEEN ELIZABETH II MED CTR,DEPT CLIN IMMUNOL,NEDLANDS,WA 6009,AUSTRALIA

来源：

ARTHRITIS AND RHEUMATISM | 1991年 / 34卷 / 02期

关键词：

D O I：

10.1002/art.1780340216

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We studied allotypes of the fourth component of complement (C4) and factor B in 76 patients with Sjogren's syndrome (SS) and in 63 normal subjects. C4A-null (C4AQ0) was found in 10 of 28 patients who had primary SS, compared with 1 of 63 control subjects (P < 0.005). In contrast, no significant difference in the frequency of any C4 allotype was observed between patients with secondary SS and control subjects. An association of HLA-DRw53 with primary SS in Japanese patients has been reported. Since there is no linkage disequilibrium between DRw53 and C4AQ0, it is possible that at least 2 genes in the major histocompatibility complex may determine susceptibility to the development of primary SS in the Japanese population.

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页码：224 / 227

页数：4

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