THE GASTRIC CYTOPROTECTIVE EFFECT OF SEVERAL SESQUITERPENE LACTONES

被引：133

作者：

GIORDANO, OS ^{[1
]}

GUERREIRO, E ^{[1
]}

PESTCHANKER, MJ ^{[1
]}

GUZMAN, J ^{[1
]}

PASTOR, D ^{[1
]}

GUARDIA, T ^{[1
]}

机构：

[1] UNIV NACL SAN LUIS,DEPT FARMACOL,RA-5700 SAN LUIS,ARGENTINA

来源：

JOURNAL OF NATURAL PRODUCTS | 1990年 / 53卷 / 04期

关键词：

D O I：

10.1021/np50070a004

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The aerial pan of Artemisia douglasiana, used in folk medicine as a cyto-protective agent against the development of peptic ulcer, was studied, its active principle dehydroleucodine [1] isolated, and its pharmacological properties analyzed. In order to establish whether or not the reported activity is particular to sesquiterpene lactones, the study of the cytoprotective activity of several related guaianolides and pseudoguaianolides from plants was undertaken. Ludartin [3], 8-angeloyloxy-3-hydroxyguaia-3(15), 10(14), 11(13)-trien-6,12-olide [4], hymenin [5], mexicanin I [6], helenanin [7], and 9-0-desacetylspathulin-2-0-angelate [8] were found to exhibit protection. Desacetoxymatricarin [2] did not show cytoprotective activity. The results obtained from the different sesquiterpene lactones studied suggest that the presence of the α-methylene-γ-lactone moiety is, in principle, a requirement for the observed antiulcerogenic activity. © 1990, American Chemical Society. All rights reserved.

引用

页码：803 / 809

页数：7

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