HEPATOCYTE GROWTH-FACTOR RAPIDLY INDUCES THE TYROSINE PHOSPHORYLATION OF 41-KDA AND 43-KDA PROTEINS IN MOUSE KERATINOCYTES

被引：24

作者：

CHATANI, Y

ITOH, A

TANAKA, E

HATTORI, A

NAKAMURA, T

KOHNO, M

机构：

[1] GIFU PHARMACEUT UNIV,DEPT BIOL,5-6-1 MITAHORA,HIGASHI KU,GIFU 502,JAPAN

[2] KYUSHU UNIV,FAC SCI,DEPT BIOL,FUKUOKA 812,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1992年 / 185卷 / 03期

关键词：

D O I：

10.1016/0006-291X(92)91706-V

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have examined the hepatocyte growth factor (HGF)-mediated changes in protein-tyrosine phosphorylation in mouse keratinocytes (PAM-212) and canine kidney epithelial cells (MDCK). In PAM-212 cells HGF and epidermal growth factor, both of which stimulated the DNA synthesis, rapidly induced the tyrosine phosphorylation of two 41-kDa and two 43-kDa proteins: increased tyrosine phosphorylation of those proteins has been commonly observed when quiescent fibroblasts are stimulated with a variety of mitogenic agents. In contrast, HGF did not stimulate the DNA synthesis but induced cell dissociation in MDCK cells; under this condition, increased tyrosine phosphorylation of the 41-kDa and 43-kDa protein was not observed. A possible role of the increased tyrosine phosphorylation of 41-kDa and 43-kDa protein in the signaling pathway of HGF is discussed. © 1992.

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页码：860 / 866

页数：7

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