THE SPECIFIC N-METHYL-D-ASPARTATE (NMDA) RECEPTOR ANTAGONIST MK-801 BLOCKS U-50,488, BUT NOT MORPHINE ANTINOCICEPTION

被引:42
作者
KEST, B [1 ]
MAREK, P [1 ]
LIEBESKIND, JC [1 ]
机构
[1] UNIV CALIF LOS ANGELES,INST NEUROPSYCHIAT,DEPT PSYCHIAT,LOS ANGELES,CA 90024
关键词
U-50,488; MORPHINE; KAPPA OPIATE RECEPTOR; MK-801; ANTINOCICEPTION;
D O I
10.1016/0006-8993(92)91173-C
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The effect of the specific NMDA receptor antagonist MK-801 on antinociception produced by the kappa-opiate receptor agonist U-50,488 and the mu-receptor agonist morphine was assessed using the tail-flick test in rats. MK-801 (0.05 and 0.1 mg/kg) antagonized antinociception induced by all three doses of U-50,488 (7.5, 15 and 30 mg/kg), and potentiated antinociception induced by the lower (1 mg/kg) but not higher (5 mg/kg) dose of morphine. Naloxone at a dose of 1.0 but not 0.1 mg/kg blocked U-50,488 antinociception, indicating that MK-801 affects opiate antinociception. The present results are the first to suggest a critical role for the NMDA receptor in opiate antinociception involving the kappa-receptor.
引用
收藏
页码:139 / 142
页数:4
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