THE MITSUNOBU REACTION - A NOVEL METHOD FOR THE SYNTHESIS OF BIFUNCTIONAL MALEIMIDE LINKERS

被引：54

作者：

WALKER, MA

机构：

[1] Bristol-Myers Squibb, Pharmaceutical Research Institute, Wallingford, CT 06492

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 05期

关键词：

D O I：

10.1016/S0040-4039(00)75785-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Compounds 1-7 were synthesized from maleimide and the corresponding alcohols using a novel application of the Mitsunobu reaction. This procedure allows the direct formation of a variety of bifunctional linker compounds.

引用

页码：665 / 668

页数：4

共 25 条

[1]

BRAISH TF, 1992, SYNLETT, P979

[2]

FEENEY RE, 1987, INT J PEPT PROT RES, V29, P145

[3] DEVELOPMENT OF AN ASYMMETRIC APPROACH TO THE 3,8-DIAZABICYCLO[3.2.1]OCTANE MOIETY OF QUINOCARCIN VIA INTERMOLECULAR 1,3-DIPOLAR CYCLOADDITIONS OF PHOTOCHEMICALLY GENERATED AZOMETHINE YLIDES [J].

GARNER, P ;

HO, WB ;

GRANDHEE, SK ;

YOUNGS, WJ ;

KENNEDY, VO .

JOURNAL OF ORGANIC CHEMISTRY, 1991, 56 (20) :5893-5903

[4] CHEMICAL CROSS-LINKS OF PROTEINS BY USING BIFUNCTIONAL REAGENTS [J].

HAN, KK ;

RICHARD, C ;

DELACOURTE, A .

INTERNATIONAL JOURNAL OF BIOCHEMISTRY, 1984, 16 (02) :129-145

[5] CYCLIC CARBOXYLIC MONOIMIDES [J].

HARGREAVES, MK ;

PRITCHARD, JG ;

DAVE, HR .

CHEMICAL REVIEWS, 1970, 70 (04) :439-+

[6]

HUGHES DL, 1992, ORGANIC REACTIONS, V42

[7] IMMOBILIZED CATALYTIC ANTIBODIES IN AQUEOUS AND ORGANIC-SOLVENTS [J].

JANDA, KD ;

ASHLEY, JA ;

JONES, TM ;

MCLEOD, DA ;

SCHLOEDER, DM ;

WEINHOUSE, MI .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (24) :8886-8888

[8]

MEANS GF, 1990, BIOCONJUGATE CHEM, P1

[9] MALEAMIC AND CITRACONAMIC ACIDS, METHYL ESTERS, AND IMIDES [J].

MEHTA, NB ;

PHILLIPS, AP ;

LUI, FF ;

BROOKS, RE .

JOURNAL OF ORGANIC CHEMISTRY, 1960, 25 (06) :1012-1015

[10] A FACILE SYNTHESIS OF CHIRAL BICYCLIC LACTAMS UTILIZED IN THE FORMATION OF CHIRAL QUATERNARY CARBON-COMPOUNDS [J].

MEYERS, AI ;

LEFKER, BA ;

SOWIN, TJ ;

WESTRUM, LJ .

JOURNAL OF ORGANIC CHEMISTRY, 1989, 54 (17) :4243-4246

← 1 2 3 →