NON-INTERACTION OF SPIRONOLACTONE MEDICATION AND CORTISOL METABOLISM IN MAN

被引：6

作者：

ABSHAGEN, U

SPORL, S

LAGE, M

机构：

[1] FREIE UNIV BERLIN,KLINIKUM STEGLITZ,DEPT INTERNAL MED,BERLIN,FED REP GER

[2] FREIE UNIV BERLIN,KLINIKUM STEGLITZ,DEPT CLIN PHARMACOL,BERLIN,FED REP GER

来源：

KLINISCHE WOCHENSCHRIFT | 1978年 / 56卷 / 03期

关键词：

Canrenone; Cenrenoate-potassium; Cortisol plasma levels; Liver failure; Normals; Spironolactone;

D O I：

10.1007/BF01478568

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In 5 healthy subjects and in 5 patients with decompensated liver diseases, the concentrations of cortisol, canrenone and canrenoate-K were determined after single doses and after a long-term treatment with spironolactone. The concentrations of the metabolites of spironolactone were determined fluorimetrically, those of cortisol by a highly specific radioimmunoassay with previous chromatographic separation. As a result, non-interaction between spironolactone medication and cortisol metabolism, even at high dose and long-term treatment conditions, was established neither in normal test subjects nor in patients with liver failure. © 1978 Springer-Verlag.

引用

页码：135 / 138

页数：4

共 17 条

[1] SOLID-PHASE RADIOIMMUNOASSAY OF ESTRADIOL-17BETA [J].