FURTHER OBSERVATIONS ON IMMUNIZATION OF SHEEP AGAINST SCHISTOSOMA-MANSONI AND S BOVIS USING IRRADIATION-ATTENUATED SCHISTOSOMULA OF HOMOLOGOUS AND HETEROLOGOUS SPECIES

被引：29

作者：

BICKLE, QD

TAYLOR, MG

JAMES, ER

NELSON, GS

HUSSEIN, MF

ANDREWS, BJ

DOBINSON, AR

MARSHALL, TFDC

机构：

[1] Winches Farm Field Station, London School of Hygiene and Tropical Medicine

[2] Faculty of Veterinary Science, University of Khartoum

[3] Tropical Epidemiology Unit, London School of Hygiene and Tropical Medicine

来源：

PARASITOLOGY | 1979年 / 78卷 / APR期

关键词：

D O I：

10.1017/S0031182000049234

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

This paper describes further characteristics of the immunization of sheep against schistosomes using live, irradiated schistosomula. Sheep immunized with a non-virulent strain of Schistosoma mattheei were protected against a more virulent strain of the same species for over a year. As there was no evidence that the irradiated parasites were able to persist this long, it was concluded that the vaccine had induced a sterile resistance. Heterologous vaccination, using irradiated S. mattheei schistosomula to immunize against S. bovis or irradiated 8. mansoni schistosomula to immunize against S. mattheei, failed to induce any protection. © 1979, Cambridge University Press. All rights reserved.

引用

页码：185 / 193

页数：9

共 12 条

[1] STUDIES ON PATHOGENESIS OF A STRAIN OF SCHISTOSOMA-MATTHEEI MAINTAINED IN HAMSTERS [J].