ANALOGS OF MONENSIN WITH A MODIFIED C-25-C-26 MOIETY - NA+/K+ SELECTIVITY AND BIOLOGICAL-ACTIVITY

被引：25

作者：

GABOYARD, C

DAUPHIN, G

VAUFREY, F

JEMINET, G

机构：

[1] Laboratoire de Chimie Organique Biologique, Aubière, 63177, U.R.A. 485 du C.N.R.S., Universite Blaise Pscal

来源：

AGRICULTURAL AND BIOLOGICAL CHEMISTRY | 1990年 / 54卷 / 05期

关键词：

D O I：

10.1080/00021369.1990.10870088

中图分类号：

S3 [农学（农艺学）];

学科分类号：

0901 ;

摘要：

C25–C26 chemical derivatives of monensin (1) were prepared: 25-dehydroxymethyl, 25-oxo (2); 25,26-isopropyliden (3); 25-O-methyl (4); 26-O-acyl (5); 26-O-[N-chlorophenyl]carbamoyl (6); and 26-O-[N-chIorophenyl, N-methyl]carbamoyl (7). Measurements of Na+ and K+ extractions in a water/toluene–butanol (70:30) system by these analogs showed the key role of the C[26]H2–OH arm for the stability and selectivity of 1:1 complexes formed by monensin. The antibiotic activity and toxicity in mice were determined in relation to the Na+/K+ cationic affinity. © 1990 by the Japan Society for Bioscience, Biotechnology, and Agrochemistry. All rights reserved.

引用

页码：1149 / 1155

页数：7

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