DRUG-INTERACTION BETWEEN RIFAMPICIN AND COTRIMOXAZOLE IN PATIENTS WITH TUBERCULOSIS

被引：10

作者：

BHATIA, RS

UPPAL, R

MALHI, R

BEHERA, D

JINDAL, SK

机构：

[1] POSTGRAD INST MED EDUC & RES,DEPT PHARMACOL,CHANDIGARH 160012,INDIA

[2] POSTGRAD INST MED EDUC & RES,DEPT PULM MED,CHANDIGARH 160012,INDIA

来源：

HUMAN & EXPERIMENTAL TOXICOLOGY | 1991年 / 10卷 / 06期

关键词：

D O I：

10.1177/096032719101000609

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

1 Patients (n = 15) who were admitted with complications of tuberculosis, were given antitubercular therapy (ATT) with rifampicin (RIF), for a minumum period of 15 d, and cotrimoxazole (CTZ), concurrently, for 5-10 d. 2 The serum RIF levels were measured before the start of CTZ treatment and at the end of its administration. 3 The plasma half-life (t1/2) of RIF increased significantly from 1.92 +/- 0.57 h to 2.31 +/- 0.134 h after CTZ treatment. 4 The mean serum levels of RIF increased significantly at 4 and 6 h after CTZ administration.

引用

页码：419 / 421

页数：3

共 8 条

[1] UPDATE ON RIFAMPIN DRUG-INTERACTIONS [J].