SYNTHESIS AND SEPARATION OF 3-O-METHYL-2-FLUORODOPA AND 6-[F-18]-FLUORODOPA

被引：8

作者：

ADAM, MJ

JIVAN, S

机构：

[1] Triumf, Vancouver, British Columbia, V6T 2A3

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 01期

关键词：

FLUORODOPA; DOPAMINE METABOLISM;

D O I：

10.1002/jlcr.2580310106

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

3-O-Methyl-2- and 6-[F-18]-fluorodopa were synthesized in 8 % radiochemical yield by the direct fluorination of a protected L-dopa derivative with [F-18]-acetyl hypofluorite. The 2- and 6-fluoro isomers were separated and purified by reverse phase HPLC.

引用

页码：39 / 43

页数：5

共 4 条

[1]

ADAM MJ, 1986, J NUCL MED, V27, P1462

[2] DETERMINATION OF PLASMA [F-18] 6-FLUORODOPA DURING POSITRON EMISSION TOMOGRAPHY - ELIMINATION AND METABOLISM IN CARBIDOPA TREATED SUBJECTS [J].