RENAL ONCOCYTOMA WITH A TRANSLOCATION T(911)(P23Q13)

被引：32

作者：

FUZESI, L ^{[1
]}

GUNAWAN, B ^{[1
]}

BRAUN, S ^{[1
]}

BOECKMANN, W ^{[1
]}

机构：

[1] RHEIN WESTFAL TH AACHEN, SCH MED, DEPT UROL, AACHEN, GERMANY

来源：

JOURNAL OF UROLOGY | 1994年 / 152卷 / 02期

关键词：

TRANSLOCATION (GENETICS); CARCINOMA; RENAL CELL; DIAGNOSIS; DIFFERENTIAL;

D O I：

10.1016/S0022-5347(17)32766-0

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of renal oncocytoma and confirm a tumor type specific translocation between chromosomes 9 and 11, that is t(9;11)(p23;q13q23). Each of the 45 cytogenetically analyzed metaphases of tumor cells showed a translocation of the long arm of chromosome 11 at q13 to chromosome 9 at 9p23 and to chromosome 20 at 20q13 that resulted in the following karyotype: 46,XX,der(11)ins(9;11)(p23;q13q23)ins(20;11)(q13;q23q25),del(22q13). Since genes encoding mitochondrial enzymes are clustered around the translocation site of chromosomes 11 and 20, they may have a role in the tumorigenesis of renal oncocytoma. In addition, if the development of oncocytomas shows different cytogenetic pathways the cytogenetic aberration of t(9;11)(p23; q12q13) can be of diagnostic help in differentiating a subset of oncocytoma from renal cell carcinoma.

引用

页码：471 / 472

页数：2

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