ANTIHEPATOTOXIC AND IMMUNOSTIMULANT PROPERTIES OF IRIDOID GLYCOSIDES OF SCROPHULARIA-KOELZII

被引：40

作者：

GARG, HS

BHANDARI, SPS

TRIPATHI, SC

PATNAIK, GK

PURI, A

SAXENA, R

SAXENA, RP

机构：

[1] CENT DRUG RES INST, DIV PHARMACOL, LUCKNOW 226001, UTTAR PRADESH, INDIA

[2] CENT DRUG RES INST, DIV MED CHEM, LUCKNOW 226001, UTTAR PRADESH, INDIA

[3] CENT DRUG RES INST, DIV BIOCHEM, LUCKNOW 226001, UTTAR PRADESH, INDIA

来源：

PHYTOTHERAPY RESEARCH | 1994年 / 8卷 / 04期

关键词：

SCROPHULARIA KOELZII; IRIDOID GLYCOSIDES; HEPATOPROTECTIVE; IMMUNOSTIMULANT;

D O I：

10.1002/ptr.2650080407

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The alcoholic extract of the aerial parts of Scrophularia koelzii (100 mg/kg p.o. X 7 days) significantly protected the rat liver against thioacetamide induced toxicity. On its further fractionation, activity was localized in the chloroform fraction from which four iridoid glycosides, namely scropolioside-A, koelzioside, harpagoside and 6-0-(3''-O-p-methoxy-cinnamoyl)-alpha-L-rhamnopyranosyl catalpol were isolated. Among these, scropolioside-A showed maximum hepatoprotective activity. Immunostimulant response was observed with all the four iridoids with harpagoside exhibiting maximum induction of immune response.

引用

页码：224 / 228

页数：5

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