INTRAVESICAL ATROPINE AND SUPPRESSION OF DETRUSOR HYPERCONTRACTILITY IN THE NEUROPATHIC BLADDER - A PRELIMINARY-STUDY

被引：22

作者：

GLICKMAN, S ^{[1
]}

TSOKKOS, N ^{[1
]}

SHAH, PJR ^{[1
]}

机构：

[1] ROYAL NATL ORTHOPAED HOSP,SPINAL INJURIES UNIT,STANMORE,MIDDX,ENGLAND

来源：

PARAPLEGIA | 1995年 / 33卷 / 01期

关键词：

INTRAVESICAL; ATROPINE; DETRUSOR; NEUROPATHIC BLADDER; ANTICHOLINERGIC DRUGS;

D O I：

10.1038/sc.1995.9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Twelve patients with detrusor hypercontractility secondary to spinal cord lesions were treated with intravesical atropine sulphate. Five patients expelled the solution almost immediately. In the seven patients who retained the solution the cystometric capacity increased by a mean of 301 ml (P < 0.01). The volume at which an unstable contraction occurred increased by a mean of 190 ml (P < 0.05) and the volume at which a urinary leak occurred increased by a mean of 297 ml (P < 0.05). The maximum hyperreflexic detrusor contraction pressure was reduced by a mean of 24 cm water (P < 0.05). No significant reduction in end fill pressure or compliance was observed though the increase in compliance approached significance. No side effects were observed and no differences were observed in pupillary reactions, blood pressure or pulse after the instillation of atropine.

引用

页码：36 / 39

页数：4

共 11 条

[1]

Ukimura O., Effects of intravesically administered anticholiner¬gics, beta-adrenergic stimulant and alpha-adrenergic blocker on bladder function II unanaesthetised rats, Tohoku J Exp Med, 170, pp. 251-260, (1993)

[2]

Kato K., Et al., In vitro intravesical instillation of anticholinergic, antispasmodic and calcium blocking agents to decrease bladder contractility, Urolint, 47, pp. 36-38, (1991)

[3]

Kato K., Et al., In vitro intravesical instillation of anticholinergic, antispasmodic and calcium blocking agents (Rabbit whole blad¬der model), Jurol, 141, pp. 1471-1475, (1989)

[4]

Brendler C.B., Radebaugh L.C., Mohler J.L., Topical oxybutynin chloride for relaxation of dysfunctional bladders, J Urol, 141, pp. 1350-1352, (1989)

[5]

Connor J.P., Et al., Early cystometrograms can predict the response to intravesical instillation of oxybutynin chloride in myelomeningocoele patients, J Urol, 151, pp. 1045-1047, (1994)

[6]

Weese D.L., Roskamp D.A., Leach G.E., Zimmern P.E., Intra¬vesical oxybutynin chloride: Experience with 42 patients, Uro¬logy, 41, pp. 527-530, (1993)

[7]

Greenfield S.P., Fera M., The use of intravesical oxybutynin chloride in children with neurogenic bladder, J Urol, 146, 2, pp. 532-534, (1991)

[8]

Madersbacher H., Jilg G., Control of detrusor hyperreflexia by the intravesical instillation of oxybutynin hydrochloride, Para¬plegia, 29, pp. 84-90, (1991)

[9]

Innes R.I., Nickerson M., Atropine scopolamine and related antimuscarinic drugs, Pharmacological Basis of Therapeutics, pp. 514-532, (1975)

[10]

Hinderline P.H., Gundert-Remy U., Schmidlin O., Integrated pharmacokinetics and pharmacodynamics of atropine in healthy humans, Pharmacokinetics J Pharm Sci, 74, pp. 703-710, (1985)

← 1 2 →