ALTROMYCINS, NOVEL PLURAMYCIN-LIKE ANTIBIOTICS .2. ISOLATION AND ELUCIDATION OF STRUCTURE

A novel complex of Gram-positive antibiotics was produced from the fermentation of an actinomycete culture AB 1246E-26. The antibiotics were recovered from the whole fermentation broth by extraction with organic solvent and isolated using counter-current chromatography. UV and IR data place these compounds m the anthraquinone-derived class of antibiotics. Mass spectral and NMR data indicate a new complex of compounds related to, but distinctly different from the pluramycin type antibiotics. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.