FURTHER-STUDIES ON THE SELECTIVITY OF DUP-753, A NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONIST

被引：21

作者：

WONG, PC

TAM, SW

HERBLIN, WF

TIMMERMANS, PBMWM

机构：

[1] Du Pont Merck Pharmaceutical Company., Wilmington, DE

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 196卷 / 02期

关键词：

ANGIOTENSIN-II RECEPTOR ANTAGONISTS; ANTIHYPERTENSIVE AGENTS; RENIN-ANGIOTENSIN SYSTEM; (RECEPTORS);

D O I：

10.1016/0014-2999(91)90429-T

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This study demonstrates the high selectivity of DuP 753 for angiotensin II (AII) receptors as it did not inhibit the contractions or radioligand bindings od endothelin, neurotensin, substance P, opioids, dopamine-2, serotonin-2, phencyclidine, acetylcholine agonists and glycine (strychnine-insensitive) and basic fibroblast growth factor but blocked the contraction of AII.

引用

页码：201 / 203

页数：3

共 10 条

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