MOLECULAR-CLONING OF CDNA-ENCODING ADIPOGENESIS INHIBITORY FACTOR AND IDENTITY WITH INTERLEUKIN-11

被引：138

作者：

KAWASHIMA, I ^{[1
]}

OHSUMI, J ^{[1
]}

MITAHONJO, K ^{[1
]}

SHIMODATAKANO, K ^{[1
]}

ISHIKAWA, H ^{[1
]}

SAKAKIBARA, S ^{[1
]}

MIYADAI, K ^{[1
]}

TAKIGUCHI, Y ^{[1
]}

机构：

[1] SANKYO CO LTD,BIOSCI RES LABS,2-58 HIROMACHI 1-CHOME,SHINAGAWA KU,TOKYO 140,JAPAN

来源：

FEBS LETTERS | 1991年 / 283卷 / 02期

关键词：

ADIPOGENESIS INHIBITORY FACTOR; INTERLEUKIN-11; CDNA CLONING; BONE MARROW STROMAL CELL;

D O I：

10.1016/0014-5793(91)80587-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A cDNA encoding a novel adipogenesis inhibitory factor (AGIF) that inhibits the process of adipogenesis in mouse 3T3-L1 preadipocytes was cloned from a cDNA library of the human bone marrow-derived stromal cell line KM-102. The cloned cDNA contains an open reading frame coding for an AGIF precursor of 199 amino acids. Analysis of the sequence of this cDNA revealed identity of this factor with a recently reported novel cytokine, designated interleukin-11 (IL-11). AGIF/IL-11 may play an important role in stromal cell-associated hematopoiesis through its regulatory action on adipocyte differentiation in the bone marrow microenvironment.

引用

页码：199 / 202

页数：4

共 30 条

[1]

ALLEN TD, 1984, EXP HEMATOL, V12, P517

[2] IDENTITY OF TUMOR NECROSIS FACTOR AND THE MACROPHAGE-SECRETED FACTOR CACHECTIN [J].

BEUTLER, B ;

GREENWALD, D ;

HULMES, JD ;

CHANG, M ;

PAN, YCE ;

MATHISON, J ;

ULEVITCH, R ;

CERAMI, A .

NATURE, 1985, 316 (6028) :552-554

[3]

BEUTLER BA, 1985, J IMMUNOL, V135, P3972

[4] CONDITIONS CONTROLLING PROLIFERATION OF HEMATOPOIETIC STEM-CELLS INVITRO [J].

DEXTER, TM ;

ALLEN, TD ;

LAJTHA, LG .

JOURNAL OF CELLULAR PHYSIOLOGY, 1977, 91 (03) :335-344

[5] ADIPOGENESIS IN A MURINE BONE-MARROW STROMAL CELL-LINE CAPABLE OF SUPPORTING B-LINEAGE LYMPHOCYTE GROWTH AND PROLIFERATION - BIOCHEMICAL AND MOLECULAR CHARACTERIZATION [J].

GIMBLE, JM ;

DORHEIM, MA ;

CHENG, Q ;

MEDINA, K ;

WANG, CS ;

JONES, R ;

KOREN, E ;

PIETRANGELI, C ;

KINCADE, PW .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1990, 20 (02) :379-387

[6]

GIMBLE JM, 1989, MOL CELL BIOL, V57, P4587

[7] SUBLINES OF MOUSE 3T3 CELLS THAT ACCUMULATE LIPID [J].

GREEN, H ;

KEHINDE, O .

CELL, 1974, 1 (03) :113-116

[8] GENERATION OF FUNCTIONAL CLONAL CELL-LINES FROM HUMAN-BONE MARROW STROMA [J].

HARIGAYA, K ;

HANDA, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (10) :3477-3480

[9] TYPE-BETA TRANSFORMING GROWTH-FACTOR CONTROLS THE ADIPOGENIC DIFFERENTIATION OF 3T3 FIBROBLASTS [J].

IGNOTZ, RA ;

MASSAGUE, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (24) :8530-8534

[10]

JABLONS D, 1990, FASEB J, V4, pA1713

← 1 2 3 →