STABILITY OF MEROPENEM AND EFFECT OF 1-BETA-METHYL SUBSTITUTION ON ITS STABILITY IN THE PRESENCE OF RENAL DEHYDROPEPTIDASE-I

被引：113

作者：

FUKASAWA, M ^{[1
]}

SUMITA, Y ^{[1
]}

HARABE, ET ^{[1
]}

TANIO, T ^{[1
]}

NOUDA, H ^{[1
]}

KOHZUKI, T ^{[1
]}

OKUDA, T ^{[1
]}

MATSUMURA, H ^{[1
]}

SUNAGAWA, M ^{[1
]}

机构：

[1] SUMITOMO PHARMACEUT CO LTD, RES LABS, 3-1-98 KASUGADE NAKA, KONOHANA KU, OSAKA 554, JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 07期

关键词：

D O I：

10.1128/AAC.36.7.1577

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The stability of meropenem in the presence of renal dehydropeptidase I (DHP-I) varied extremely with the animal source of the enzyme. Meropenem, compared with imipenem, was rather easily hydrolyzed by DHP-Is from mice, rabbits, and monkeys, while it showed a higher resistance to guinea pig and beagle dog DHP-Is. In addition, meropenem was four times more resistant than imipenem to human DHP-I. The 1-beta-methyl substituent on carbapenems, i.e., meropenem and 1-beta-methyl imipenem, made them considerably more resistant to mouse and swine DHP-Is than the 1-unsubstituted derivatives are.

引用

页码：1577 / 1579

页数：3

共 23 条

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