MODULATION OF AMNIOTIC ADENYLATE-CYCLASE AND CAMP-PHOSPHODIESTERASE BY PROSTAGLANDINS E(1) AND F2-ALPHA

被引：3

作者：

VESCE, F ^{[1
]}

TARABBIA, C ^{[1
]}

FARINA, A ^{[1
]}

TRAVAGLI, S ^{[1
]}

PARESCHI, MC ^{[1
]}

PORTOLAN, A ^{[1
]}

BIONDI, C ^{[1
]}

机构：

[1] UNIV FERRARA,IST FISIOL GEN,FERRARA,ITALY

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 1994年 / 37卷 / 02期

关键词：

ADENYLATE CYCLASE; CAMP-PDE; AMNION; LABOR; PGE(1); PGF(2-ALPHA);

D O I：

10.1159/000292529

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The action of prostaglandins E(1) and F-2 alpha on adenylate cyclase and cAMP phosphodiesterase was assayed in cell membrane fractions of amnion obtained before and after labor from term physiological pregnancies. Both prostaglandins stimulate the activity of adenylate cyclase in a dose-dependent manner. After spontaneous delivery both prostaglandins stimulate the activity of phosphodiesterase at lower doses and inhibit it at higher ones while the stimulatory effect of low doses is missing before labor. Such a behavior could represent a mechanism for the preservation of the cAMP-mediated processes throughout the entire event of delivery.

引用

页码：77 / 82

页数：6

共 20 条

[1] EFFECTS OF FETAL URINARY CORTICOSTEROIDS, CATECHOLAMINES AND KALLIKREIN ON PGE2 SYNTHESIS IN MONOLAYER-CULTURES OF HUMAN AMNION AND CHORION CELLS [J].