STERIC CONTROL OF N-ACETYLGALACTOSAMINE IN GLYCOSIDIC BOND FORMATION

被引：25

作者：

YULE, JE ^{[1
]}

WONG, TC ^{[1
]}

GANDHI, SS ^{[1
]}

QIU, DX ^{[1
]}

RIOPEL, MA ^{[1
]}

KOGANTY, RR ^{[1
]}

机构：

[1] BIOMIRA INC,EDMONTON,AB T6N 1H1,CANADA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 38期

关键词：

D O I：

10.1016/0040-4039(95)01442-K

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Acetylgalactosamine, protected with a 4,6-cyclic acetal followed by selective acylation at 3-OH, provides an excellent donor for the synthesis of rx-glycosides, particularly the cancer associated antigens such as Tn, TF, Sialyl-Tn and Sialyl-TF. This fast and efficient synthesis is easily adaptable for commercial production of mucin type glycopeptides with O-linked carbohydrate structures which are currently being investigated as vaccines against cancers.

引用

页码：6839 / 6842

页数：4

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