MULTI-COPY NUCLEAR PSEUDOGENES OF MITOCHONDRIAL-DNA REVEAL RECENT ACUTE GENETIC CHANGES IN THE HUMAN GENOME

被引：20

作者：

HU, GX

THILLY, WG

机构：

[1] Center for Environmental Health Sciences, Massachusetts Institute of Technology, Cambridge, 02139, MA

来源：

CURRENT GENETICS | 1995年 / 28卷 / 05期

关键词：

MITOCHONDRIAL DNA; MULTI-COPY; PSEUDOGENE; EVOLUTION;

D O I：

10.1007/BF00310808

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Four nuclear pseudogenes homologous to the 10031-10195-bp region of the human mitochondrial genome were detected by constant denaturant capillary electrophoresis. Among them, one pseudogene is present as at least five copies in each cell, in accordance with our previous observations of multi-copy mitochondrial DNA pseudogenes. The presence of multiple identical copies of pseudogenes suggests that the human genome underwent a series of genetic changes, including gene amplifications, very recently in evolutionary history, i.e., within the last 390 000 years.

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页码：410 / 414

页数：5

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