AN IN VITRO SYSTEM FOR STUDY OF MYELIN SYNTHESIS

被引：87

作者：

SMITH, ME

机构：

[1] Neurology Service, U.S. Veterans Administration Hospital, Stanford University School of Medicine, Department of Medicine, Palo Alto, California

来源：

JOURNAL OF NEUROCHEMISTRY | 1969年 / 16卷 / 01期

关键词：

D O I：

10.1111/j.1471-4159.1969.tb10345.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— A system for the study of short‐term myelin synthesis in spinal cord tissue in vitro with [U‐14C]glucose as a lipid and protein precursor is described. The rates of lipid and protein incorporation into myelin are age‐dependent, but do not appear to behave similarly. Uptake of labelled carbon is most rapid in monophosphoinositide and lecithin, and slowest in cerebroside sulphate. Myelin protein seems to retain more metabolic activity than does the lipid. These findings are interpreted as support for the unit membrane hypothesis for myelin rather than the subunit model. Copyright © 1969, Wiley Blackwell. All rights reserved

引用

页码：83 / &

共 25 条

[1] ENZYME INACTIVITY OF MYELIN - HISTOCHEMICAL AND BIOCHEMICAL EVIDENCE [J].

ADAMS, CWM ;

DAVISON, AN ;

GREGSON, NA .

JOURNAL OF NEUROCHEMISTRY, 1963, 10 (06) :383-+

[2]

ANSELL GB, 1966, VARIATION CHEMICA ED, P46

[3] PREPARATION + SOME PROPERTIES OF PURIFIED MYELIN FROM CENTRAL NERVOUS SYSTEM [J].

AUTILIO, LA ;

TERRY, RD ;

NORTON, WT .

JOURNAL OF NEUROCHEMISTRY, 1964, 11 (01) :17-&

[4]

CUZNER ML, 1965, ANN NY ACAD SCI, V122, P86

[5]

DAVISON A. N., 1965, ADVANCE LIPID RES, V3, P171

[6] METABOLISM OF CELLULAR MEMBRANE SULPHOLIPIDS IN RAT BRAIN [J].

DAVISON, AN ;

GREGSON, NA .

BIOCHEMICAL JOURNAL, 1966, 98 (03) :915-&

[7]

DAVISON AN, 1964, METABOLISM PHYSIOLOG, P527

[8]

DAWSON RMC, 1964, METABOLISM PHYSIO ED, P527

[9] MATURATION OF RAT BRAIN MYELIN [J].

ENG, LF ;

NOBLE, EP .

LIPIDS, 1968, 3 (02) :157-&

[10]

FOLCH J, 1957, J BIOL CHEM, V226, P497

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