EUDRAGIT-E MICROSPHERES CONTAINING BACAMPICILLIN - PREPARATION BY SOLVENT REMOVAL METHODS

被引：26

作者：

BOGATAJ, M

MRHAR, A

KRISTL, A

KOZJEK, F

机构：

[1] Department of Pharmacy, Faculty of Natural Sciences and Technology, University of Ljubljana, 61000, Ljubljana, Yugoslavia

来源：

JOURNAL OF MICROENCAPSULATION | 1991年 / 8卷 / 03期

关键词：

D O I：

10.3109/02652049109069567

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Eudragit E microspheres containing bacampicillin hydrochloride were prepared by solvent evaporation and solvent extraction methods. Three different systems of solvents were used: methyl acetate, acetone and methanol/liquid paraffin. The success of the procedures depended mostly on the lipophilicity of the solvent. The particle size of microspheres was determined by sieve analysis. The results showed that the average size of microspheres is influenced greatly by the type of solvent. Scanning electron microscopy was used for observation of the shape of microspheres. Microspheres prepared by the solvent evaporation method in systems with acetone and methyl acetate were all of a regular spherical shape. The surface of all other microspheres was folded. The influence of magnesium stearate content in microspheres was also studied in terms of different methods, solvents and processing conditions.

引用

页码：401 / 406

页数：6

共 6 条

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