PREOPERATIVE DIAGNOSIS OF ACROMEGALY BY GROWTH HORMONE-RELEASING FACTOR RADIOIMMUNOASSAY

被引：4

作者：

BARTH, RJ ^{[1
]}

CONSTANT, RB ^{[1
]}

PARKER, MW ^{[1
]}

MUELLER, GL ^{[1
]}

KOVACS, K ^{[1
]}

THORNER, MO ^{[1
]}

机构：

[1] WILFORD HALL USAF MED CTR,ENDOCRINE SERV,LACKLAND AFB,TX 78236

来源：

MILITARY MEDICINE | 1991年 / 156卷 / 07期

关键词：

D O I：

10.1093/milmed/156.7.375

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acromegaly was diagnosed in a 37-year-old woman with classical physical and biochemical findings; an enlarged sella on computed tomography suggested the presence of a pituitary macroadenoma. Radiologic evidence of a lung mass prompted radioimmunoassay of plasma growth hormone-releasing factor (7,500 pg/ml; normal < 100 pg/ml). After resection of a bronchial carcinoid, which stained positive for growth hormone-releasing factor, circulating growth hormone-releasing factor levels normalized. Subsequently, her clinical, biochemical, and radiologic evidence for acromegaly resolved. This case represents the first reported use of the human pancreatic growth hormone-releasing factor 1-40 radioimmunoassay to preoperatively diagnose this rare etiology of acromegaly.

引用

页码：375 / 378

页数：4