SOLUBLE GLYCOPROTEIN-D BLOCKS HERPES-SIMPLEX VIRUS TYPE-1 INFECTION OF RAT EYES

被引：13

作者：

MARTIN, LB ^{[1
]}

MONTGOMERY, PC ^{[1
]}

HOLLAND, TC ^{[1
]}

机构：

[1] WAYNE STATE UNIV, SCH MED, DEPT IMMUNOL & MICROBIOL, 540 E CANFIELD AVE, DETROIT, MI 48201 USA

来源：

JOURNAL OF VIROLOGY | 1992年 / 66卷 / 09期

关键词：

D O I：

10.1128/JVI.66.9.5183-5189.1992

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Herpes simplex virus type 1 (HSV-1) ocular infection in rats was blocked by treating the eyes with UV-inactivated virions containing glycoprotein D (gD) prior to ocular challenge. In contrast, rats treated with UV-inactivated virions lacking gD were not protected. A soluble, truncated form of HSV-2 gD (gD-2t) also protected against ocular infection. Treatment with gD-2t not only reduced mortality but also restricted progression of pathology and reduced the amount of viral antigen in the cornea. Host antibody or alpha/beta interferon responses to the gD-2t treatment were not detected. These results are similar to those observed in cell culture (D. C. Johnson, R. L. Burke, and T. Gregory, J. Virol. 64:2569-2576, 1990). The in vivo effect of exogenous gD is consistent with blocking of a cell surface gD receptor or with an inhibitory interaction of gD with virions.

引用

页码：5183 / 5189

页数：7

共 38 条

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