COMPUTER-ASSISTED OPTIMIZATION OF THE GAS-CHROMATOGRAPHIC SEPARATION OF EQUINE ESTROGENS

被引：16

作者：

JAYATILAKA, A ^{[1
]}

POOLE, CF ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202

来源：

JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1993年 / 617卷 / 01期

关键词：

D O I：

10.1016/0378-4347(93)80416-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The pharmaceutically important conjugated estrogens of the type excreted by pregnant mares were baseline-resolved by gas chromatography (GC) on a SE-30 fused-silica open tubular column after acid hydrolysis and conversion to their tert.-butyldimethylsilyl derivatives. The temperature-programmed conditions were optimized with the aid of DryLab GC software with excellent agreement between the predicted and experimental results. The composition of conjugated estrogens in Premarin tablets is described as an application of the method.

引用

页码：19 / 27

页数：9

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