POSITIVELY CHARGED SUBMICRON EMULSIONS - A NEW-TYPE OF COLLOIDAL DRUG CARRIER

被引：40

作者：

ELBAZ, E ^{[1
]}

ZEEVI, A ^{[1
]}

KLANG, S ^{[1
]}

BENITA, S ^{[1
]}

机构：

[1] HEBREW UNIV JERUSALEM, SCH PHARM, DEPT PHARM, POB 12065, JERUSALEM, ISRAEL

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 96卷 / 1-3期

关键词：

SUBMICRON EMULSION; COLLOIDAL DRUG CARRIER;

D O I：

10.1016/0378-5173(93)90237-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A positively charged submicron emulsion was prepared and stabilized by forming a mixed film comprising phospholipids, poloxamer and stearylamine at the o/w interface of the oil droplets. This was confirmed concomitantly by the selective adsorption of the thiocyanate anion and the lack of adsorption of Ca2+ onto the emulsified oil droplets of the actual emulsions. The incorporation of various drugs in the new type of submicron emulsions altered neither the nature of the surface charge nor the mean droplet size. These results clearly demonstrated that the positively charged submicron emulsion can be used as a new type of colloidal drug carrier.

引用

页码：R1 / R6

页数：6

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