NEUROPEPTIDE FF-CONTAINING EFFERENT PROJECTIONS FROM THE MEDIAL HYPOTHALAMUS OF RAT - A PHASEOLUS-VULGARIS-LEUKOAGGLUTININ STUDY

被引:43
作者
AARNISALO, AA
PANULA, P
机构
[1] UNIV HELSINKI, DEPT ANAT, SF-00014 HELSINKI, FINLAND
[2] ABO ACAD UNIV, DEPT BIOL, SF-20520 TURKU, FINLAND
基金
英国医学研究理事会; 芬兰科学院;
关键词
D O I
10.1016/0306-4522(94)00459-I
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Neuropeptide FF (FMRFamide-like peptide, morphine-modulating peptide) is an octapeptide isolated from the bovine brain. There is evidence that neuropeptide FF participates in the modulation of nociceptive mechanisms. Neuropeptide FF acts through its own receptors which are distinct from the opiate receptors. In the rat brain neuropeptide FF is found in two major cell populations. We have studied the efferent connections of the hypothalamic neuropeptide FF-containing cell group, which is located in the medial hypothalamus between the dorsomedial, ventromedial and periventricular hypothalamic nuclei. By using an anterograde tracing method (Phaseolus vulgaris leucoagglutinin) combined with double-staining immunohistochemistry we characterized the connections of this cell group with the limbic system, certain hypothalamic nuclei, periaqueductal gray and with the solitary tract nucleus. In the limbic system, the major targets were the lateral septal nucleus, bed nucleus of stria terminalis and certain subnuclei in the amygdala. These connections suggest that neuropeptide FF may act, in addition to its well-characterized action in the sensory system, in limbic functions. Efferent connections to the periaqueductal gray suggest that neuropeptide FF may modulate the opiate mediated analgesia at this site. Good correlation between our results and receptor autoradiography. support the idea that the terminal areas which our results show are target areas of the neuropeptide FF-containing system.
引用
收藏
页码:175 / 192
页数:18
相关论文
共 71 条
[1]   NALOXONE REVERSAL OF ANALGESIA PRODUCED BY BRAIN-STIMULATION IN HUMAN [J].
ADAMS, JE .
PAIN, 1976, 2 (02) :161-166
[2]  
AKERSSON TR, 1988, BRAIN RES, V451, P381
[3]   ANTAGONISM OF STIMULATION-PRODUCED ANALGESIA BY NALOXONE, A NARCOTIC-ANTAGONIST [J].
AKIL, H ;
MAYER, DJ ;
LIEBESKIND, JC .
SCIENCE, 1976, 191 (4230) :961-962
[4]   AUTORADIOGRAPHIC DISTRIBUTION OF RECEPTORS TO FLFQPQRFAMIDE, A MORPHINE-MODULATING PEPTIDE, IN RAT CENTRAL-NERVOUS-SYSTEM [J].
ALLARD, M ;
ZAJAC, JM ;
SIMONNET, G .
NEUROSCIENCE, 1992, 49 (01) :101-116
[5]   CHARACTERIZATION OF RAT SPINAL-CORD RECEPTORS TO FLFQPQRFAMIDE, A MAMMALIAN MORPHINE MODULATING PEPTIDE - A BINDING STUDY [J].
ALLARD, M ;
GEOFFRE, S ;
LEGENDRE, P ;
VINCENT, JD ;
SIMONNET, G .
BRAIN RESEARCH, 1989, 500 (1-2) :169-176
[6]   AN ANALYSIS OF THE ORIGINS OF THE CHOLINERGIC AND NONCHOLINERGIC SEPTAL PROJECTIONS TO THE HIPPOCAMPAL-FORMATION OF THE RAT [J].
AMARAL, DG ;
KURZ, J .
JOURNAL OF COMPARATIVE NEUROLOGY, 1985, 240 (01) :37-59
[7]   CHOLINERGIC AND NON-CHOLINERGIC SEPTO-HIPPOCAMPAL PROJECTIONS - A DOUBLE-LABEL HORSERADISH PEROXIDASE-ACETYLCHOLINESTERASE STUDY IN THE RABBIT [J].
BAISDEN, RH ;
WOODRUFF, ML ;
HOOVER, DB .
BRAIN RESEARCH, 1984, 290 (01) :146-151
[8]   OPIATE AND STIMULUS-PRODUCED ANALGESIA - FUNCTIONAL-ANATOMY OF A MEDULLOSPINAL PATHWAY [J].
BASBAUM, AI ;
CLANTON, CH ;
FIELDS, HL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (12) :4685-4688
[9]   THE PERIAQUEDUCTAL GRAY PROJECTIONS TO THE RAT SPINAL TRIGEMINAL, RAPHE MAGNUS, GIGANTOCELLULAR PARS ALPHA AND PARAGIGANTOCELLULAR NUCLEI ARISE FROM SEPARATE NEURONS [J].
BEITZ, AJ ;
MULLETT, MA ;
WEINER, LL .
BRAIN RESEARCH, 1983, 288 (1-2) :307-314
[10]   EFFERENT CONNECTIONS OF THE LATERAL HYPOTHALAMIC AREA OF THE RAT - AN AUTORADIOGRAPHIC INVESTIGATION [J].
BERK, ML ;
FINKELSTEIN, JA .
BRAIN RESEARCH BULLETIN, 1982, 8 (05) :511-526