EFFECT OF ANTI-LYMPHOCYTE GLOBULIN (ALG) ON HUMAN-LYMPHOCYTES INVITRO - INHIBITION OF LYMPHOTOXIN PRODUCTION AS A SENSITIVE INDICATOR FOR ALG ACTIVITY

被引：3

作者：

EIFE, GW ^{[1
]}

EIFE, RF ^{[1
]}

BRENDEL, W ^{[1
]}

机构：

[1] UNIV MUNICH,INST CHIRURG FORSCH,D-8000 MUNICH 2,FED REP GER

来源：

CELLULAR IMMUNOLOGY | 1979年 / 46卷 / 01期

关键词：

D O I：

10.1016/0008-8749(79)90243-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The effect of antilymphocyte globulin (ALG) on lymphocyte function in the presence or absence of complement was investigated by comparing (i) ALG-induced blast-cell transformation, (ii) lymphotoxin production and (iii) its effect on PHA-induced blast-cell transformation, and on (iv) lymphotoxin production and (v) its cytolytic effect on lymphocytes. The most striking observation was that even extremely low doses of ALG were able to suppress significantly the lymphotoxin production without affecting other lymphocyte functions or cell viability; this effect was found to be independent of complement. From the comparisons of the mitogen-induced lymphocyte function in the presence of varying doses of ALG and PHA it can be concluded that ALG exerts its inhibitory effect on lymphokine production most likely by interfering with mitogen recognition rather than lymphokine secretion. © 1979.

引用

页码：35 / 47

页数：13

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