OPTIMAL HEMATOCRIT FOR CANINE SKELETAL-MUSCLE DURING RHYTHMIC ISOTONIC EXERCISE

被引:48
作者
GAEHTGENS, P
KREUTZ, F
ALBRECHT, KH
机构
[1] Institut für Normale und Pathologische Physiologie der UniversitÄt, Köln 41, D-5000
来源
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY AND OCCUPATIONAL PHYSIOLOGY | 1979年 / 41卷 / 01期
关键词
Dynamic work; Hemoconcentration; Hemodilution; Optimal hematocrit; Oxygen delivery; Skeletal muscle;
D O I
10.1007/BF00424466
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Contractile power, blood flow, O2-uptake. and O2-extraction during isotonic, rhythmic exercise were determined in the isolated canine gastrocnemius muscle during perfusion with blood with hematocrits between 0.21 and 0.81. The results obtained in 36 measurements on nine muscles showed that maximal O2-delivery to the muscle is found at hematocrits between 0.5 and 0.6. Both in the range of hemodilution, and in the range of extreme hemoconcentration, O2-delivery decreases significantly. O2-consumption and contractile power of the muscles are almost unaffected in the hematocrit range between 0.4 and 0.7; beyond and below this hematocrit range both parameters decrease. O2-extraction is virtually constant in the hematocrit range between 0.3 and 0.6, but increases both below and above these hematocrit levels. It is concluded that due to reduced vasodilatory reserve in working skeletal muscle compared to resting muscle the optimal hematocrit is shifted to higher values. © 1979 Springer-Verlag.
引用
收藏
页码:27 / 39
页数:13
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