BIOSYNTHESIS OF THE 25-KDA PROTEIN IN THE MACROGAMETES ZYGOTES OF PLASMODIUM-FALCIPARUM

被引:18
作者
FRIES, HCW
LAMERS, MBAC
VANDEURSEN, J
PONNUDURAI, T
MEUWISSEN, JHET
机构
[1] Institute of Medical Parasitology, University of Nijmegen, 6525 GA Nijmegen
关键词
Actinomycin D; Colchicine; Plasmoduim falciparum; Pulse labeling;
D O I
10.1016/0014-4894(90)90025-8
中图分类号
R38 [医学寄生虫学]; Q [生物科学];
学科分类号
07 ; 0710 ; 09 ; 100103 ;
摘要
Synthesis of the 25-kDa protein in the early midgut stages of Plasmodium falciparum was studied, using metabolic inhibitors (colchicine and actinomycin D) and pulse-labeling experiments. Experiments with colchicine showed that, immediately after induction of macrogametogenesis, 25-kDa protein synthesis occurs in both fertilized and nonfertilized macrogametes. The amount of 25-kDa protein synthesized increased slowly during time. Experiments with actinomycin D revealed that the slow increase of synthesis may be dependent on de novo messenger RNA synthesis. © 1990.
引用
收藏
页码:229 / 235
页数:7
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