SELECTIVE AND SENSITIVE DETERMINATION OF LACTONE AND HYDROXY ACID FORMS OF CAMPTOTHECIN AND 2 DERIVATIVES (CPT-11 AND SN-38) BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY WITH FLUORESCENCE DETECTION

被引：10

作者：

AKIMOTO, K

GOTO, A

OHYA, K

机构：

[1] Pharmaceutical Formulation Research Centre, Research Institute, Daiichi Pharmaceutical Co. Ltd., Edogawa-ku, Tokyo, 134

来源：

JOURNAL OF CHROMATOGRAPHY | 1991年 / 588卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(91)85018-B

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and rapid ion-pair high-performance liquid chromatographic (HPLC) method for the simultaneous determination of the lactone and hydroxy acid forms of camptothecin and its derivatives CPT-11 and SN-38 was developed. The method allows the hydroxy acid form to be eluted before the lactone form for each compound. The application of this method is limited by the minimum interval between subsequent injections and the void time for starting a measurement. However, it is possible to determine the lactone and hydroxy acid forms in aqueous solutions at the pH and the temperature near to biological conditions.

引用

页码：165 / 170

页数：6

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