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VASOACTIVE-INTESTINAL-PEPTIDE ANTAGONIST RETARDS THE DEVELOPMENT OF NEONATAL BEHAVIORS IN THE RAT

被引：70
作者：
HILL, JM
GOZES, I
HILL, JL
FRIDKIN, M
BRENNEMAN, DE
机构：
[1] PEPTIDE DESIGN, GERMANTOWN, MD 20874 USA
[2] TEL AVIV UNIV, SACKLER SCH MED, DEPT CHEM PATHOL, TEL AVIV, ISRAEL
[3] NIMH, CLIN SCI LAB, BIOSTAT UNIT, BETHESDA, MD 20892 USA
[4] WEIZMANN INST SCI, DEPT ORGAN CHEM, IL-76100 REHOVOT, ISRAEL
来源：
PEPTIDES | 1991年 / 12卷 / 01期
关键词：
VASOACTIVE INTESTINAL PEPTIDE; VIP; NEUROPEPTIDE; NEUROBEHAVIORAL DEVELOPMENT; NEUROTROPHIC FACTOR; DEVELOPMENTAL SIGNS; BRAIN DEVELOPMENT; VIP HYBRID ANTAGONIST;
D O I：
10.1016/0196-9781(91)90186-S
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Based on the demonstrated neurotrophic activity of VIP in vitro, a recently designed VIP antagonist was used to assess the role of this neuropeptide in the behavioral development of rats. Rats received daily subcutaneous injections from birth to day 14. Observations of developmental milestones/behaviors were made daily for 21 days. Of the measures of behavioral development tested, the time to surface right on day 4 and the day of onset for forelim placing, hindlimb placing, forelimb grasping and air righting were significantly retarded by the antagonist. Cotreatment with VIP prevented the antagonist-induced delay. These results suggest that VIP activity is important in the development of select complex motor behaviors.
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页码：187 / 192
页数：6
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