3-DIMENSIONAL WAVES OF EXCITATION DURING DICTYOSTELIUM MORPHOGENESIS

被引：79

作者：

STEINBOCK, O ^{[1
]}

SIEGERT, F ^{[1
]}

MULLER, SC ^{[1
]}

WEIJER, CJ ^{[1
]}

机构：

[1] UNIV MUNICH,INST ZOOL,W-8000 MUNICH 2,GERMANY

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 15期

关键词：

CHEMOTAXIS; NUMERICAL SIMULATIONS; SELF-ORGANIZATION; REACTION-DIFFUSION COUPLING;

D O I：

10.1073/pnas.90.15.7332

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cells in Dictyostelium slugs follow well-defined patterns of motion. We found that the chemotactic cell response is controlled by a scroll wave of messenger concentration in the highly excitable prestalk zone of the slug that decays in the less-excitable prespore region into planar wave fronts. This phenomenon is investigated by numerical solutions of partial differential equations that couple local nonlinear kinetics and diffusive transport of the chemotactic signal. In the interface of both regions a complex twisted scroll wave is formed that reduces the wave frequency in the prespore zone. The spatio-temporal dynamics of waves and filaments are followed over 33 periods of rotation. These results yield an explanation of collective self-organized cell motion in a multicellular organism.

引用

页码：7332 / 7335

页数：4

共 24 条

[1] A MODEL FOR FAST COMPUTER-SIMULATION OF WAVES IN EXCITABLE MEDIA [J].