STRUCTURAL ASPECTS OF OPTICAL RESOLUTIONS - OPTICAL RESOLUTION OF (R,S)-MANDELIC ACID - DSC AND X-RAY STUDIES OF THE DIASTEREOISOMERIC SALTS

被引:23
作者
ACS, M
NOVOTNYBREGGER, E
SIMON, K
ARGAY, G
机构
[1] SWISS FED INST TECHNOL,INST ORGAN CHEM,CH-8092 ZURICH,SWITZERLAND
[2] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1525 BUDAPEST,HUNGARY
来源
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1992年 / 11期
关键词
D O I
10.1039/p29920002011
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The diastereoisomeric salt pair formed during the resolution of mandelic acid (MA) using (R)-2-tert-butyl-3-methylimidazolidin-4-one (BMI) has been studied by DSC and X-ray crystallographic methods. Both diastereoisomers crystallize in a monoclinic system with space group P2(1); unit cell parameters for the less soluble R-R isomer: a = 11.484(1), b = 6.027(1), c = 11.951 (1) angstrom, beta = 98.77 (1)-degrees, V = 817.5 (3) angstrom3; for the more soluble R-S diastereoisomer a = 11.170(1), b = 5.975(1), c = 13.327(1) angstrom, beta = 111.95(1)-degrees, V = 825.0(3) angstrom3. The structures were solved by direct methods and refined to a final R value of 0.044 and 0.057, respectively.
引用
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页码:2011 / 2017
页数:7
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