STRUCTURAL ASPECTS OF OPTICAL RESOLUTIONS - OPTICAL RESOLUTION OF (R,S)-MANDELIC ACID - DSC AND X-RAY STUDIES OF THE DIASTEREOISOMERIC SALTS

被引：23

作者：

ACS, M

NOVOTNYBREGGER, E

SIMON, K

ARGAY, G

机构：

[1] SWISS FED INST TECHNOL,INST ORGAN CHEM,CH-8092 ZURICH,SWITZERLAND

[2] HUNGARIAN ACAD SCI,CENT RES INST CHEM,H-1525 BUDAPEST,HUNGARY

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2 | 1992年 / 11期

关键词：

D O I：

10.1039/p29920002011

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diastereoisomeric salt pair formed during the resolution of mandelic acid (MA) using (R)-2-tert-butyl-3-methylimidazolidin-4-one (BMI) has been studied by DSC and X-ray crystallographic methods. Both diastereoisomers crystallize in a monoclinic system with space group P2(1); unit cell parameters for the less soluble R-R isomer: a = 11.484(1), b = 6.027(1), c = 11.951 (1) angstrom, beta = 98.77 (1)-degrees, V = 817.5 (3) angstrom3; for the more soluble R-S diastereoisomer a = 11.170(1), b = 5.975(1), c = 13.327(1) angstrom, beta = 111.95(1)-degrees, V = 825.0(3) angstrom3. The structures were solved by direct methods and refined to a final R value of 0.044 and 0.057, respectively.

引用

页码：2011 / 2017

页数：7

共 20 条

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