SUPPRESSION OF A LIGAND OPERATED MEMBRANE CURRENT BY THE EPILEPTOGENIC AGENT PENTYLENETETRAZOL IN OOCYTES OF XENOPUS-LAEVIS AFTER INJECTION OF RAT-BRAIN RNA

被引：6

作者：

BLOMS, P

MUSSHOFF, U

MADEJA, M

MUSCHNITTEL, K

KUHLMANN, D

SPENER, F

SPECKMANN, EJ

机构：

[1] INST BIOCHEM,MUNSTER,GERMANY

[2] INST SPEZIELLE ZOOL & VERGLEICHENDE EMBRYOL,MUNSTER,GERMANY

[3] INST EXPTL EPILEPSIEFORSCH,MUNSTER,GERMANY

来源：

NEUROSCIENCE LETTERS | 1992年 / 147卷 / 02期

关键词：

EPILEPSY; PENTYLENETETRAZOL; LIGAND OPERATED CHANNEL; SEROTONIN; XENOPUS OOCYTE; RNA INJECTION;

D O I：

10.1016/0304-3940(92)90583-S

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of the epileptogenic substance pentylenetetrazol (PTZ) on ligand operated membrane channels were studied. For this purpose serotonin (5-HT) sensitive channels were expressed in RNA injected oocytes of Xenopus laevis. With simultaneous application of both substances, the response to 5-HT was reduced and eventually abolished by PTZ with increasing concentrations (5-100 mM). A reduction of the 5-HT response also appeared when PTZ was applied in various intervals (15 and 240 s) before 5-HT. It may be assumed that PTZ produces a component of its epileptogenic effect by acting on ligand operated membrane channels.

引用

收藏

页码：155 / 158

页数：4

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