EFFICACY OF IVERMECTIN IN THE TREATMENT OF STRONGYLOIDIASIS COMPLICATING AIDS

被引：56

作者：

TORRES, JR ^{[1
]}

ISTURIZ, R ^{[1
]}

MURILLO, J ^{[1
]}

GUZMAN, M ^{[1
]}

CONTRERAS, R ^{[1
]}

机构：

[1] HOSP PRIVADO,CTR MED CARACAS,CARACAS,VENEZUELA

来源：

CLINICAL INFECTIOUS DISEASES | 1993年 / 17卷 / 05期

关键词：

D O I：

10.1093/clinids/17.5.900

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nine adult male homosexuals who were infected with the human immunodeficiency virus (five with AIDS-defining conditions) and harbored Strongyloides stercoralis received ivermectin on a compassionate basis for persistent intestinal infection. Hyperinfection was present in all cases. Ivermectin was given either as a single oral dose (200 mug/kg) or on a multidose schedule (200 mug/kg.d) on days 1, 2, 15, and 16. All seven patients who received multiple doses showed sustained clinical and parasitological cure, whereas one of two patients who received single-dose therapy relapsed promptly and fatally. Remissions have been maintained for at least 7 months and up to 3 years of follow-up. Ivermectin appears promising in the treatment of strongyloidiasis in patients with AIDS. Because of the risk of hyperinfection and/or disseminated disease, multidose courses are warranted. We are not aware of other reports describing the efficacy of antiparasitic drugs for strongiloidiasis in patients with AIDS.

引用

页码：900 / 902

页数：3

共 15 条

[1] PERSISTENT DIARRHEA IN ZAIRIAN AIDS PATIENTS - AN ENDOSCOPIC AND HISTOLOGICAL STUDY [J].